Larazotide
THE GUT HEALTH PEPTIDE
Larazotide is a synthetic eight-amino-acid peptide designed to support intestinal barrier function by regulating tight junctions between cells in the gut lining. It works as a zonulin antagonist, helping prevent excessive permeability that can allow substances to pass through the gut wall. Primarily researched in celiac disease, larazotide has been studied for its ability to reduce gastrointestinal symptoms when gluten exposure occurs. Research continues to explore its safety, tolerability, and potential benefits beyond celiac disease.
PROTECT YOUR GUT’S HEALTH
Supports Gut Barrier Integrity: Helps tighten the junctions between intestinal cells to reduce “leaky gut”-type permeability.
May Reduce GI Symptoms: In studies with gluten challenges, larazotide has been linked to fewer gastrointestinal symptoms compared with placebo.
Adjunct to Standard Care: Designed to be used alongside dietary management (like a gluten-free diet in celiac disease) rather than replacing it.
Ongoing Research: Investigated not only for celiac disease but also in other inflammation-related settings where gut barrier function matters.
RELEVANT STUDIES
Read below for studies about the potential benefits of larazotide.
Phase II Randomized Controlled Trial in Celiac Disease — This early human study tested larazotide acetate in people with celiac disease eating gluten or avoiding it. Lower doses appeared to limit gluten-related symptom worsening, and the peptide was well tolerated overall.
Systematic Review & Meta-Analysis of Larazotide (ScienceDirect) — A review of several clinical trials found larazotide was safe and helped reduce gastrointestinal symptoms in celiac patients during gluten challenges, though not a cure and best used with diet management.
Mechanistic Evidence on Tight Junction Protection — Detailed research shows larazotide helps stabilize tight junction proteins and the gut barrier at the molecular level, which helps prevent gluten peptides from crossing into deeper tissue.
FAQs
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Larazotide is a synthetic peptide studied for its ability to regulate tight junctions in the gut lining and support intestinal barrier function.
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It acts as a zonulin antagonist — blocking signals that would otherwise loosen tight junctions — helping preserve the gut’s selective barrier.
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Most research has focused on celiac disease, especially during gluten exposure, though scientists are exploring other inflammatory conditions linked to gut permeability.
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Trials typically report a safety profile similar to placebo, with no major serious adverse events directly linked to larazotide in studied doses.
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No. It is studied as a complement to, not a replacement for, strict dietary management in celiac disease.
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It’s given orally in capsule form multiple times per day; however, specific dosing outside studies isn’t established.
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Click here to schedule your consultation. A licensed physician will contact you to discuss if larazotide is right for you.
Huemn offers Larazotide peptide therapy in Houston, serving clients from The Heights, Vintage Park, Cypress, and surrounding areas seeking advanced immune and longevity support.
Disclaimer: The statements and content presented on this website have not been evaluated by the U.S. Food and Drug Administration (FDA). We do not diagnose, treat, or claim to treat any health conditions. All services provided by Huemn are intended solely to promote overall wellness, and information on this site is published for educational purposes. Always consult with a healthcare professional before making any decisions related to your health.